Linear 1 3-diarylpropanoids
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 5 G
4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. It also modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity. This product is intended for research use only.
- Regulates adipocyte differentiation via PPARγ activation
- Modulates adipokine expression and secretion involved in insulin sensitivity
- Increases mRNA expression of adipogenic genes during differentiation
- Reduces upregulated mRNA expression of IL-6, PAI-1, and MCP-1
- Causes an increase in PPARγ expression during differentiation
- Exhibits antiproliferative activity and cytotoxicity against various human cell lines
- Targets PPARγ
- Derived from Piperaceae Piper nigrum Linn.
- Classified as flavonoids, chalcones
Medchemexpress LLC PI3K/AKT-IN-1 | 3033069-84-7 | 99.6% | C23H23N5O4S | 25 MG
PI3K/AKT-IN-1 is an effective dual inhibitor of PI3K and AKT, exhibiting anticancer activity by inhibiting the PI3K/AKT axis and inducing caspase 3-dependent apoptosis. This compound has high cytotoxic activity against leukemia K562 and breast cancer MCF-7 cell lines, and is intended for research use only.
- Demonstrates high cytotoxic activity, particularly against leukemia cell line K562 (IC50=2.62 μM) and breast cancer cell line MCF-7 (IC50=3.22 μM)
- Promotes S-phase cell cycle arrest and induces apoptosis in K562 cells
- Significantly reduces the expression of PI3K, p-PI3K, AKT, p-AKT, Cyclin D1, and NF-κB
- Found to be non-toxic and well-tolerated in animal studies, with an LD50 greater than 2000 mg/kg
- Soluble in DMSO at 50 mg/mL
- Solid, off-white to light yellow appearance
Apexbio Technology LLC Phloretin is a dihydrochalcone, a type of natural phenols. 60-82-2. MFCD00002288
Phloretin is a dihydrochalcone, a type of natural phenols. 60-82-2. MFCD00002288
![eMolecules 18916-17-1 | Naringin dihydrochalcone | AA Blocks LLC | MFCD08436145 | 582.555 | C27H34O14 | 0.000 | C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2Oc2cc(O)c(C(=O)CCc3ccc(O)cc3)c(O)c2)[C@H](O)[C@H](O)[C@H]1O | 1g | 410159523](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC3966903.jpg-250.jpg)
eMolecules 18916-17-1 | Naringin dihydrochalcone | AA Blocks LLC | MFCD08436145 | 582.555 | C27H34O14 | 0.000 | C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2Oc2cc(O)c(C(=O)CCc3ccc(O)cc3)c(O)c2)[C@H](O)[C@H](O)[C@H]1O | 1g | 410159523
Naringin dihydrochalcone | AA Blocks LLC | 18916-17-1 | MFCD08436145 | 582.555 | C27H34O14 | 0.000 | C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2Oc2cc(O)c(C(=O)CCc3ccc(O)cc3)c(O)c2)[C@H](O)[C@H](O)[C@H]1O | 1g | 410159523